Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1515	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1515	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1516	non-methylated cytosine‚Äìguanine dinucleotide (Cg) motifs Click for more detail	Bacterial, viral and mitochondrial Dna	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with metastatic colorectal carcinoma (CRC)	plasmacytoid dendritic cells (pDC) and B cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24816725	2014	Pubchem_assay
PRRID_1516	non-methylated cytosine‚Äìguanine dinucleotide (Cg) motifs Click for more detail	Bacterial, viral and mitochondrial Dna	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with metastatic colorectal carcinoma (CRC)	plasmacytoid dendritic cells (pDC) and B cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24816725	2014	Pubchem_assay
PRRID_1565	phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	B-Lymphocytes	Toll-IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801688	2014	Pubchem_assay
PRRID_1565	phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	B-Lymphocytes	Toll-IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801688	2014	Pubchem_assay
PRRID_1566	phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B-Lymphocytes	Toll-IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801688	2014	Pubchem_assay
PRRID_1566	phosphorothioated unmethylated CpG-ODNs (Oligodeoxynucleotide) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	CpG ODN induces class switching to isotypes IgG2a, IgG2b and IgG3 in mice, while suppressing the production of the IgG1 and IgE isotypes; furthermore, it stimulates class switching from IgM to the more pathogenic IgG1, IgG2 and IgG3 in human	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B-Lymphocytes	Toll-IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24801688	2014	Pubchem_assay
PRRID_1568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell	endosomal receptor	Q99MB1.fasta	Q99MB1	905	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	ELISA	24829411	2014	Pubchem_assay
PRRID_1570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell	endosomal receptor	Q99MB1.fasta	Q99MB1	905	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	ELISA	24829411	2014	Pubchem_assay
PRRID_1571	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Surface (Exogenous)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1571	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Surface (Exogenous)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1572	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	cell surface	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24825342	2014	Pubchem_assay
PRRID_1572	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	cell surface	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24825342	2014	Pubchem_assay
PRRID_1573	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1573	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1574	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Dendritic Cell, B-lymphocyte	cell compartment	Q0PQ88.fasta	Q0PQ88	896	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1574	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Chicken	Dendritic Cell, B-lymphocyte	cell compartment	Q0PQ88.fasta	Q0PQ88	896	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1575	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1575	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1576	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1576	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1577	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1577	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1578	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	human MSCs (hMSCs) and murine MSCs (mMSCs)	intracellular receptors	Q99MB1.fasta	Q99MB1	905	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1578	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	human MSCs (hMSCs) and murine MSCs (mMSCs)	intracellular receptors	Q99MB1.fasta	Q99MB1	905	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1579	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	human MSCs (hMSCs) and murine MSCs (mMSCs)	intracellular receptors	O15455.fasta	O15455	904	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1579	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	human MSCs (hMSCs) and murine MSCs (mMSCs)	intracellular receptors	O15455.fasta	O15455	904	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1580	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24771854	2014	Pubchem_assay
PRRID_1580	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24771854	2014	Pubchem_assay
PRRID_1581	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24771854	2014	Pubchem_assay
PRRID_1581	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24771854	2014	Pubchem_assay
PRRID_1582	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24771328	2014	Pubchem_assay
PRRID_1582	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24771328	2014	Pubchem_assay
PRRID_1583	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24771328	2014	Pubchem_assay
PRRID_1583	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24771328	2014	Pubchem_assay
PRRID_1584	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	European and African Children	NA	TRIF	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24743542	2014	Pubchem_assay
PRRID_1584	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	European and African Children	NA	TRIF	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	ELISA	24743542	2014	Pubchem_assay
PRRID_1585	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induces the expression of IFN-c, IFN-a1 and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1585	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induces the expression of IFN-c, IFN-a1 and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1586	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	M1ZMQ4.fasta	M1ZMQ4	913	play a role in antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1586	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	M1ZMQ4.fasta	M1ZMQ4	913	play a role in antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1587	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a1 (TLR22a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	NA
PRRID_1587	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a1 (TLR22a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	NA
PRRID_1588	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a2 (TLR22a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5BM14.fasta	B5BM14	925	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1588	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a2 (TLR22a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5BM14.fasta	B5BM14	925	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1589	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24720881	2014	Pubchem_assay
PRRID_1589	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISA	24720881	2014	Pubchem_assay
PRRID_1591	PolyU Click for more detail	analog of ssRNA(others)	NA	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1591	PolyU Click for more detail	analog of ssRNA(others)	NA	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1606	RNA Click for more detail	Enterovirus 71 (virus)	NA	NA	Nucleic Acid	Natural	The binding of ligand leads to the activation of the nuclear factor	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1606	RNA Click for more detail	Enterovirus 71 (virus)	NA	NA	Nucleic Acid	Natural	The binding of ligand leads to the activation of the nuclear factor	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1607	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1607	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1608	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1608	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1612	self DNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1612	self DNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1613	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Synthetic	induce the production of proinflammatory cytokines in pDC	RIG-1	Rig-like receptor (RLR)	Human	epithelial cells, myeloid cells, and CNS cells	Cytosol of cell	O95786.fasta	O95786	925	Recognize distinct viruses and produce the antiviral immune changes that initiate an innate response	NA	24829146	2014	Pubchem_assay
PRRID_1613	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Synthetic	induce the production of proinflammatory cytokines in pDC	RIG-1	Rig-like receptor (RLR)	Human	epithelial cells, myeloid cells, and CNS cells	Cytosol of cell	O95786.fasta	O95786	925	Recognize distinct viruses and produce the antiviral immune changes that initiate an innate response	NA	24829146	2014	Pubchem_assay
PRRID_1614	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1614	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1615	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1615	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1616	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1616	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1618	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1618	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1619	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1619	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1620	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1620	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1622	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1622	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1623	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1623	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1624	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1624	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1625	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1625	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1626	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1626	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1627	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1627	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1628	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1628	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1629	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1629	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1630	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1630	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1631	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1631	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay

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